What does Viagra Connect do?
When a man is sexually stimulated, impulses from the brain reach the cavernous nerve which releases nitric oxide (NO) at nerve endings in the penis. The NO diffuses across the endothelial cells into smooth muscle and stimulates the enzyme, guanylate cyclase, to convert GTP into cyclic GMP (cGMP).
Cyclic GMP starts a further cascade of biochemical reactions which results in smooth muscle relaxation and the cavernous bodies fill with blood and become rigid. Cyclic GMP is normally broken down by the enzyme PDE5 to GMP, which terminates the pathway and produces detumescence (Erection will subside).
Viagra Connect mode of action
Viagra Connect inhibits the action of this enzyme thus increasing cGMP levels and maintaining these levels for longer. Hence Viagra Connect helps a man attain and maintain an erection in response to sexual stimulation.
- PDE5 inhibitor augments the normal physiological response to sexual stimulation
- There is no effect in the absence of sexual stimulation
How long does it take Viagra Connect to work?
Because Viagra Connect is quickly absorbed, it only takes around 30–60 minutes to be effective, sexual stimulation is required for it to work. Viagra Connect will still be effective up to 4 hours after it is taken. After sex, the erection will go away as it would normally.
When taken with a high fat meal, the body takes longer to absorb Viagra Connect.
This means it will take a while longer to work, and this should be advised when recommending to customers.